Return of the psychedelics: Psilocybin for treatment resistant depression
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2019, Pharmacology and TherapeuticsCitation Excerpt :In response to promising results in the treatment of depression with classic psychedelics (both within and outside of cancer contexts), a number of reviews and commentaries have been published. A commonality is acknowledgement of promising findings but recognition of the early stages of this research and the need for larger studies investigating methodological variations, in particular the need for randomized research in non-cancer related treatment-resistant depression, continued research on potential risks, and additional research on potential mechanisms (e.g., dos Santos et al., 2016; Mahapatra and Gupta, 2017; Patra, 2016; Cowen, 2016; McCorvy et al., 2016). A challenge not typically recognized in commentaries is that, despite widespread agreement that systematic and rigorous following is essential, substantial funding is required for large trials and mechanistic studies, and to date, federal funding for such follow-up research has not been provided.
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2018, Clinics in DermatologyCitation Excerpt :The psilocybe mushroom is perhaps best known for its hallucinogenic psilocybin, a monamine/indole alkaloid occurring naturally in the mushroom (Figure 8). Psilocybin is a prodrug of psilocin (4-hydroxy-dimethyltryptamine), a serotonin agonist in the human brain that can have impressive effects on perception, cognition, and emotion, producing psychosis-like clinical manifestations.206 Although it has been used for thousands of years for medicinal purposes, it is better known as a recreational drug and often viewed disparagingly by the medical field.207
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