Asian Journal of Psychiatry
Volume 3, Issue 2 , Pages 64-66 , June 2010

No gross abnormality of plasma homocysteine after acute methionine loading in clinically stabilized patients with schizophrenia

Received 31 March 2009 ,Revised 31 January 2010 ,Accepted 7 March 2010.

References 

  1. Alexander F, Curtis GC, Sprince H, Crosley AP. l-Methionine and l-tryptophan feedings in non-psychotic and schizophrenic patients with and without tranylcypromine. J. Nerv. Ment. Dis. 1963;137:135–142
  2. Ananth JV, Ban TA, Lehmann HE, Bennett J. Nicotinic acid in the prevention and treatment of methionine-induced exacerbation of psychopathology in schizophrenics. Can. Psychiatr. Assoc. J. 1970;15(1):15–20
  3. Antun FT, et al. The effects of l-methionine (without MAOI) in schizophrenia. J. Psychiatr. Res. 1971;8(2):63–71
  4. Applebaum J, Shimon H, Sela BA, Belmaker RH, Levine J. Plasma homocysteine levels in newly admitted schizophrenic patients. J. Psychiatr. Res. 2004;4:413–416
  5. Bellamy MF, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98(18):1848–1852
  6. Berlet HH, et al. Biochemical correlates of behavior in schizophrenic patients. Schizophrenic patients receiving tryptophan and methionine or methionine together with a monoamine oxidase inhibitor. Arch. Gen. Psychiatry. 1965;13(6):521–531
  7. Brune GG, Himwich HE. Effects of methionine loading on the behavior of schizophrenic patients. J. Nerv. Ment. Dis. 1962;134:44.7-50
  8. Cohen SM, Nichols A, Wyatt R, Pollin W. The administration of methionine to chronic schizophrenic patients: a review of ten studies. Biol. Psychiatry. 1974;8(2):209–225
  9. de Jong SC, et al. Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease. Arterioscler. Thromb. Vasc. Biol. 1999;19(5):1316–1324
  10. De Jonge R, et al. Evaluation of a shorter methionine loading test. Clin. Chem. Lab. Med. 2004;42(9):1027–1031
  11. den Heijer M, et al. Homocysteine levels--before and after methionine loading—in 51 Dutch families. Eur. J. Hum. Genet. 2005;13(6):753–762
  12. Doshi S, et al. Relationship between S-adenosylmethionine. S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism. 2005;54(3):351–360
  13. Gould TD, Gottesman II. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav. 2006;5(2):113–119
  14. Haydu GG, Dhrymiotis A, Korenyi C, Goldschmidt L. Effects of methionine and hydroxychloroquine in schizophrenia. Am. J. Psychiatry. 1965;122(5):560–564
  15. Israelstam DM, et al. Abnormal methionine metabolism in schizophrenic and depressive states: a preliminary report. J. Psychiatr. Res. 1970;7(3):185–190
  16. Jus, A., Rosengarten, H., Wardaszko-Eyskowska, H., Szemis, A., 1970. Correlations Between Disturbances of Tryptophan Metabolism Provoked by Methionine, Nialamide and Tryptophan Administration and Changes of the Psychic State in Chronic Schizophrenic Patients, Department of Psychiatry, Academy of Medicine, Warsaw, Poland, Nowowiejska 27.
  17. Kakimoto Y, Sano I, Kanazawa A, Tsujio T, Kaneko Z. Metabolic effects of methionine in schizophrenic patients pretreated with a monoamine oxidase inhibitor. Nature. 1967;216(120):1110–1111
  18. Lavie L, Lavie P. Daily rhythms in plasma levels of homocysteine. J. Circadian Rhythms. 2004;2(1):5
  19. Levine J, et al. Elevated homocysteine levels in young male patients with schizophrenia. Am. J. Psychiatry. 2002;159(10):1790–1792
  20. Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol. Psychiatry. 2005;
  21. Park LC, Baldessarini RJ, Kety SS. Methionine effects on chronic schizophrenics: patients treated with monoamine oxidase inhibitors. Arch. Gen. Psychiatry. 1965;12:346–351
  22. Pollin W, Cardon PV, Kety SS. Effects of amino acid feedings in schizophrenic patients treated with iproniazid. Science. 1961;133:104–105
  23. Suliman ME, et al. Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients. Nephrol. Dial. Transplant. 2001;16(1):102–110
  24. Tsai MY. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis. 2000;149(1):131–137
  25. van der Griend R, et al. Methionine loading test is necessary for detection of hyperhomocysteinemia. J. Lab. Clin. Med. 1998;132(1):67–72

PII: S1876-2018(10)00015-8

doi: 10.1016/j.ajp.2010.03.004

Asian Journal of Psychiatry
Volume 3, Issue 2 , Pages 64-66 , June 2010